The Cocoon Platform is an automated, closed, end-to-end manufacturing solution — flexible to adapt to your process, and built to carry it from pre-clinical through commercial supply.
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Cocoon replaces manual, operator-dependent steps with a single cassette that runs your process end to end. Advanced biofeedback empowers preclinical development; industry-leading cost of manufacture enables clinical progression and commercial economics — with no bespoke robotics needed to scale out. Whether you manufacture in a centralized, decentralized, or point-of-care model, the Cocoon Platform accelerates development and reduces risk.
Fewer labour
hours
Lower cost
of goods
Greater manufacturing
density per cleanroom
Precise control of feeding, gas exchange and agitation shapes the product itself, whatever the modality. Cell performance is not something a developer can compromise on. A static vessel offers no visibility into the culture: no feedback, no adjustment, no basis for the process decisions that determine the final product.
Autologous T cells expanded on Cocoon versus G-Rex®, measured on phenotype and on function.
Cocoon produced T cells maintain stem-like memory phenotype longer than G-Rex.
TSCM cells are the least differentiated memory subset: these critically important cells self-renew, persist for years and repopulate the full effector pool after infusion. A product richer in TSCM cells keeps working after the first wave of killing is over. Higher TSCM content is repeatedly associated with deeper expansion in vivo, longer persistence and more durable response.
Cocoon produced T cells can effectively clear tumour cells at lower E:T ratios as compared to G-Rex. This means Cocoon delivers a higher quality and more potent drug product.
Start with a conversation. Our process development team can determine the feasibility of running your process on Cocoon within one week.
We deliver:
A candidate Cocoon process outline and cassette configuration
Open questions and risks worth resolving before a formal transfer
A translation timeline and cost-of-goods range for your stage
The Cocoon Platform integrates every process step for manufacturing advanced therapies — without complex modular integrations or bespoke robotics.
Cocoon is process-agnostic. Isolation, activation, transduction, expansion and harvest are configured to your protocol — the same platform supports autologous, allogeneic and non-immune cell products.
Autologous and allogeneic
Engineered receptor programs
Including CAR-NK
Vaccine and priming workflows
Reprogramming and differentiation
Flexible application development
Adherent expansion
Regenerative tissue products
Cocoon does not impose a fixed protocol. Every step is tunable to your biology. Work independently, or alongside our process development team.
Keep the media, activators and vectors your process already relies on.
Feed, wash, rock, temperature and gas set to the biology — edited by your team, or by ours.
We optimize input materials and process duration to bring cost of goods down.
The span of process durations running on Cocoon today, from minimally cultured products to extended expansion.
The Cocoon Platform is built on flexibility.
No process in place? No problem.
Fitting an existing process to an easily customizable platform? Straightforward.
Already in a clinical trial? We work with you to ensure a seamless transition and a comparable product.
Our customers have translated their processes to Cocoon in as little as six weeks. From documentation & material transfer, to protocol design and run execution.
FDA Advanced Manufacturing Technology Designation
FDA Type V Drug Master File on record
In clinical use across North America, Europe, the Middle East, and APAC
Product Dossier and Product Information File available
Cocoon Silk® brings automated alarming, remote monitoring and fleet management to your whole installed base.
Silk is how a manufacturing organization supervises Cocoon at scale. Cocoons report their status, deviations raise alarms rather than waiting to be noticed, and a single view covers every Cocoon in every facility. Silk makes a multi-site or decentralized model practical to oversee.
Every run, every site, one view
Compare runs, donors and sites
Audit-ready record of each batch
Role-based control across the fleet
Training and troubleshooting on demand
Validated, encrypted data transfer
The Octane Ecosystem is a transformative approach to delivering cell therapies at scale — technology, facilities and expertise working as one system, so a therapy that works for one patient can reach every patient who needs it. Built on 25+ years of cell therapy manufacturing and 30,000 therapies already delivered to patients.
A team shaped by decades of commercial cell therapy manufacturing
Dozens of therapies leave our facilities for patients every day
One partner from preclinical optimization through process translation, GMP readiness, facility engineering, regulatory packages, manufacturing, logistics, distribution and clinical site evaluation
GMP capacity on both sides of the Atlantic, in the US and Europe
Review the platform architecture, automated process steps, quality framework, support model, and technical specifications in one concise reference.
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Tell us where your process is today, and we will show you the shortest safe path to commercial supply.
Prefer email? cocoon@octane.bio
